Speciogynine

Speciogynine is a monoterpenoid indole alkaloid and a diastereomer of mitragynine, sharing the molecular formula C23H30N2O4, that occurs naturally as a minor alkaloid in the leaves of Mitragyna speciosa.

Molecular formula: C₂₃H₃₀N₂O₄
Systematic name: Pending verification
Natural abundance: Minor

What is Speciogynine?

Where does Speciogynine occur naturally?

Speciogynine occurs in the leaves of Mitragyna speciosa (kratom), typically as one of the minor alkaloids within the leaf alkaloid fraction.

How is Speciogynine related to mitragynine?

Speciogynine and mitragynine are both monoterpenoid indole alkaloids from Mitragyna speciosa that share the same indole scaffold; Speciogynine has the molecular formula C23H30N2O4 and mitragynine has the molecular formula C23H30N2O4.

Structure and chemistry

Speciogynine is a corynanthe-type diastereomer of mitragynine, differing in stereochemistry within the quinolizidine ring system while retaining the same indole nucleus and substituent pattern.

As a stereoisomer it carries the identical molecular formula to mitragynine and is distinguished from its relatives by chromatographic and spectroscopic analysis.

Speciogynine compared with related alkaloids

Comparison of Speciogynine with related Mitragyna alkaloids by molecular formula, systematic name, and natural abundance
Alkaloid	Molecular formula	Systematic name (IUPAC)	Natural abundance
Speciogynine	C₂₃H₃₀N₂O₄	Pending verification	Minor
Mitragynine	C₂₃H₃₀N₂O₄	Pending verification	Predominant
Speciociliatine	C₂₃H₃₀N₂O₄	Pending verification	Minor
Paynantheine	C₂₃H₂₈N₂O₄	Pending verification	Second most abundant

Sources

Structural characterization of minor indole alkaloids in Mitragyna speciosa (review)

Reviewed for scientific accuracy on 2026-07-15. This entry describes chemical structure and natural occurrence only.